GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs7615952 | 1 | rs9289275 | chr3:125648659 | LOC100125556 | chr3:125635444-125648865:+ | 0.36 | 5.33 | 1.71E-7 | Blood pressure (smoking interaction) |
| BLCA | cis | rs10935120 | 1 | rs9289471 | chr3:134230811 | ANAPC13 | chr3:134196547-134204865:- | 0.5 | 8.07 | 8.91E-15 | Height |
| BLCA | cis | rs10935120 | 1 | rs9289471 | chr3:134230811 | CEP63 | chr3:134204575-134293852:+ | 0.25 | 4.29 | 2.26E-5 | Height |
| BLCA | cis | rs10935120 | 1 | rs9289475 | chr3:134236459 | ANAPC13 | chr3:134196547-134204865:- | 0.48 | 7.66 | 1.58E-13 | Height |
| BLCA | cis | rs10935120 | 1 | rs9289475 | chr3:134236459 | CEP63 | chr3:134204575-134293852:+ | 0.22 | 3.87 | 0.000127 | Height |
| BLCA | cis | rs10935120 | 1 | rs9289476 | chr3:134237103 | ANAPC13 | chr3:134196547-134204865:- | 0.47 | 7.49 | 4.72E-13 | Height |
| BLCA | cis | rs10935120 | 1 | rs9289478 | chr3:134268619 | ANAPC13 | chr3:134196547-134204865:- | 0.47 | 7.54 | 3.54E-13 | Height |
| BLCA | cis | rs9296404 | 1 | rs9296404 | chr6:42925803 | GNMT | chr6:42928500-42931617:+ | -0.46 | -8.11 | 6.92E-15 | Plasma homocysteine levels (post-methionine load test) |
| BLCA | cis | rs9296404 | 1 | rs9296404 | chr6:42925803 | PEX6 | chr6:42931613-42946981:- | 0.67 | 11.59 | 7.59E-27 | Plasma homocysteine levels (post-methionine load test) |
| BLCA | cis | rs9296504 | 1 | rs9296504 | chr6:46629505 | SLC25A27 | chr6:46620679-46645925:+ | 0.24 | 4.9 | 1.4E-6 | QRS complex (Sokolow-Lyon) |
| BLCA | cis | rs9296504 | 1 | rs9296505 | chr6:46629841 | SLC25A27 | chr6:46620679-46645925:+ | 0.23 | 4.71 | 3.42E-6 | QRS complex (Sokolow-Lyon) |
| BLCA | cis | rs9473555 | 1 | rs9296616 | chr6:49414235 | CENPQ | chr6:49431096-49460820:+ | -0.3 | -6.07 | 3.05E-9 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs9296616 | chr6:49414235 | MUT | chr6:49398994-49431031:- | 0.25 | 4.96 | 1.07E-6 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs9296617 | chr6:49428360 | CENPQ | chr6:49431096-49460820:+ | -0.28 | -5.65 | 3.17E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs9296617 | chr6:49428360 | MUT | chr6:49398994-49431031:- | 0.28 | 5.51 | 6.48E-8 | Folate pathway vitamin levels |